In the field of breast cancer, there was an early implementation of some of the above-mentioned principles of personalised cancer medicine, namely through the therapeutic targeting of hormone receptor signalling [ 35 ]. The papyrus describes 48 generic clinical cases where rudimentary surgical procedures were used to treat wounds, fractures, and cancer, according to the different parts of the body. Both aspects have been capitalised ever since to achieve improved patient stratification in terms of accurate prognostication and treatment decisions, bringing us several steps closer to the realisation of personalised breast cancer medicine. These improvements are a huge achievement for humanity and have been accomplished over time with the contributions of many bright and passionate individuals.
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PIK3CA mutations in breast cancer: This indicates that further refinement of triaging patients with the respective treatment is needed, for implementing truly personalised cancer medicine. Emerging powerful technologies of ctDNA detection with increasing sensitivity could be also assessed as potential tools of personalised cancer screening [ 55 ]. Statistical controversies in clinical research:
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Plasma exosome microRNAs are indicative of breast cancer. Accurate translations of the medical manuscripts and the establishment of the early medical schools allowed the continuation of medical development [ 7 ]. Beyond trastuzumab and lapatinib: Hanahan D, Coussens LM.
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